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Article

Identification of a pre-active conformation of a pentameric channel receptor.

eLife - 15 Mar 2017

Menny Anaïs, Lefebvre Solène N, Schmidpeter Philipp Am, Drège Emmanuelle, Fourati Zaineb, Delarue Marc, Edelstein Stuart J, Nimigean Crina M, Joseph Delphine, Corringer Pierre-Jean

Abstract excerpt

Pentameric ligand-gated ion channels (pLGICs) mediate fast chemical signaling through global allosteric transitions. Despite the existence of several high-resolution structures of pLGICs, their dynamical properties remain elusive. Using the proton-gated channel GLIC, we engineered multiple fluorescent reporters, each incorporating a bimane and a tryptophan/tyrosine, whose close distance causes fluorescence...

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Bridged Bicyclo Compounds, Heterocyclic
Cyanobacteria
Fluorescent Dyes
Membrane Potentials
Protein Conformation, alpha-Helical

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Protein Conformation, beta-Strand

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PMID: 28294942
DOI: 10.7554/eLife.23955
PMCID: PMC5398890

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