Article

Progressive Loosening of a Dual Autoinhibitory Interface Activates PP2A-B56δ

2026-08-23

Abstract excerpt

Protein phosphatase 2A containing the B56δ regulatory subunit (PP2A-B56δ) is a critical signaling enzyme whose dysregulation is associated with cancer, neurodegenerative disorders, and Jordan's syndrome, a severe intellectual disability disorder caused by mutations in B56δ. Unlike other PP2A holoenzymes, PP2A-B56δ is regulated through a unique dual autoinhibition mechanism in which the N- and C-arms occlude the ca...

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Literature Corpus work: 6d483b43-e60d-58ac-a216-60ae7016038d
DOI: 10.64898/2026.08.19.745767

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