Article

Conformational coupling by trans-phosphorylation in calcium calmodulin dependent kinase II

2019-01-18

Abstract excerpt

The calcium calmodulin dependent protein kinase II (CaMKII) is a dodecameric holoenzyme important for encoding memory. Its activation, triggered by binding of calcium calmodulin, persists autonomously after calmodulin dissociation. One (receiver) kinase captures and subsequently phos-phorylates the regulatory domain peptide of a donor kinase forming a chained dimer as a first stage of autonomous activation. Protei...

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Literature Corpus work: 9be782fc-c332-5758-93dc-7f69568f4a4c
DOI: 10.1101/524660

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