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Article

Diversity of Functionally Permissive Sequences in the Receptor-Binding Site of Influenza Hemagglutinin.

Cell host & microbe - 14 Jun 2017

Wu Nicholas C, Xie Jia, Zheng Tianqing, Nycholat Corwin M, Grande Geramie, Paulson James C, Lerner Richard A, Wilson Ian A

Abstract excerpt

Influenza A virus hemagglutinin (HA) initiates viral entry by engaging host receptor sialylated glycans via its receptor-binding site (RBS). The amino acid sequence of the RBS naturally varies across avian and human influenza virus subtypes and is also evolvable. However, functional sequence diversity in the RBS has not been fully explored. Here, we performed a large-scale mutational analysis of the RBS of...

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Share to Antigenic Variation
Share to Hemagglutinin Glycoproteins, Influenza Virus

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Immune Evasion

Share to Influenza A Virus, H1N1 Subtype

Share to Influenza A Virus, H3N2 Subtype

Share to Receptors, Virus

Share to Sequence Analysis

Share to Virus Internalization

Source

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Identifiers

PMID: 28618270
DOI: 10.1016/j.chom.2017.05.011
PMCID: PMC5553561

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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