Article
A Perspective on the Structural and Functional Constraints for Immune Evasion: Insights from Influenza Virus.
Journal of molecular biology - 18 Aug 2017
Wu Nicholas C, Wilson Ian A
Abstract excerpt
Influenza virus evolves rapidly to constantly escape from natural immunity. Most humoral immune responses to influenza virus target the hemagglutinin (HA) glycoprotein, which is the major antigen on the surface of the virus. The HA is composed of a globular head domain for receptor binding and a stem domain for membrane fusion. The major antigenic sites of HA are located in the globular head subdomain, which is...
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