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A multimechanistic antibody targeting the receptor binding site potently cross-protects against influenza B viruses

18 Oct 2017

Abstract excerpt

Influenza B virus causes considerable disease burden worldwide annually, highlighting the limitations of current influenza vaccines and antiviral drugs. In recent years, broadly neutralizing antibodies (bnAbs) against hemagglutinin (HA) have emerged as a new approach for combating influenza. We describe the generation and characterization of a chimeric monoclonal antibody, C12G6, that cross-neutralizes...

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PMID: 29046433
DOI: 10.1126/scitranslmed.aam5752

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