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Unique binding pattern for a lineage of human antibodies with broad reactivity against influenza A virus

2 May 2022

Abstract excerpt

Abstract Most structurally characterized broadly neutralizing antibodies (bnAbs) against influenza A viruses (IAVs) target the conserved conformational epitopes of hemagglutinin (HA). Here, we report a lineage of naturally occurring human antibodies sharing the same germline gene, VH3-48/VK1-12. These antibodies broadly neutralize the major circulating strains of IAV in vitro and in vivo mainly by binding a...

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PMID: 35501328
DOI: 10.1038/s41467-022-29950-w

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