Article
The Pig-a Gene Mutation Assay in Mice and Human Cells: A Review.
Basic & clinical pharmacology & toxicology - 1 Sept 2017
Olsen Ann-Karin, Dertinger Stephen D, Krüger Christopher T, Eide Dag M, Instanes Christine, Brunborg Gunnar, Hartwig Andrea, Graupner Anne
Abstract excerpt
This MiniReview describes the principle of mutation assays based on the endogenous Pig-a gene and summarizes results for two species of toxicological interest, mice and human beings. The work summarized here largely avoids rat-based studies, as are summarized elsewhere. The Pig-a gene mutation assay has emerged as a valuable tool for quantifying in vivo and in vitro mutational events. The Pig-a locus is located...
Topics
- Animals
- Biological Assay
- Cells, Cultured
- DNA Damage
- Environmental Exposure
- Flow Cytometry
- Hemoglobinuria, Paroxysmal
- Humans
- Membrane Proteins
- Mice
- Models, Animal
- Mutagenicity Tests
- Mutagens
- Mutation
- X Chromosome