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PIG-A gene mutation as a genotoxicity biomarker in human population studies: An investigation in lead-exposed workers.

Environmental and molecular mutagenesis - 1 Jul 2020

Cao Yiyi, Wang Tuanwei, Xi Jing, Zhang Guanghui, Wang Tongshuai, Liu Weiying, You Xinyue, Zhang XinYu, Xia Zhaolin, Luan Yang

Abstract excerpt

The rodent Pig-a gene mutation assay has demonstrated remarkable sensitivity in identifying in vivo mutagens, while much less is known about the value of the human PIG-A assay for risk assessment. To obtain more evidence of its potential as a predictive biomarker for carcinogen exposure, we investigated PIG-A mutant frequencies (MFs), along with performing the Comet assay and micronucleus (MN) test, in 267...

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PMID: 32285465
DOI: 10.1002/em.22373

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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