The PIG-A gene mutation assay in human biomonitoring and disease.

doi:10.1002/em.22577

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Article

The PIG-A gene mutation assay in human biomonitoring and disease.

Environmental and molecular mutagenesis - 1 Jan 2000

Lawrence Rachel, Munn Kathryn, Naser Hamsa, Thomas Laura, Haboubi Hasan, Williams Lisa, Doak Shareen, Jenkins Gareth

Abstract excerpt

The blood cell phosphatidylinositol glycan class A (PIG-A) gene mutation assay has been extensively researched in rodents for in vivo mutagenicity testing and is now being investigated in humans. The PIG-A gene is involved in glycosyl phosphatidylinositol (GPI)-anchor biosynthesis. A single mutation in this X-linked gene can lead to loss of membrane-bound GPI anchors, which can be enumerated via corresponding...

Topics

Humans
Glycosylphosphatidylinositols
Biological Monitoring
Membrane Proteins
Mutation
Erythrocytes

Source

Open in PubMed

Identifiers

PMID: 37926486
DOI: 10.1002/em.22577

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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