Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Erythrocyte-based Pig-a gene mutation assay.

Methods in molecular biology (Clifton, N.J.) - 1 Jan 2013

Bemis Jeffrey C, Hall Nikki E, Dertinger Stephen D

Abstract excerpt

In addition to chromosomal damage, assessment of gene mutation is an important part of genotoxicity testing employed during preclinical safety testing. The Pig-a gene mutation assay is based on the loss of function of the Pig-a gene, which results in a lack of cell surface expression of specific proteins that are targeted to the surface by GPI anchors. This cell surface phenotype is readily assessed by flow...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Blood Platelets
Share to Blood Specimen Collection
Share to Centrifugation

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Erythrocytes

Share to Flow Cytometry

Share to Membrane Proteins

Share to Microspheres

Share to Mutagenicity Tests

Source

Identifiers

PMID: 23896871
DOI: 10.1007/978-1-62703-529-3_3

Genes

GPI

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Erythrocyte-based Pig-a gene mutation assay.PMID 23896871Read ↗

Erythrocyte-Based Pig-a Gene Mutation Assay.Semantic proximity Read ↗

The PIG-A gene mutation assay in human biomonitoring and disease.Semantic proximity Read ↗

The PIG-A gene mutation assay in human biomonitoring and diseaseSemantic proximity Read ↗

[The PIG-A gene as a new biomarker of mutagenesis: proof of concept and technical specifications].Semantic proximity Read ↗

The Pig-a Gene Mutation Assay in Mice and Human Cells: A Review.Semantic proximity Read ↗

The in vivo Pig-a assay: A report of the International Workshop On Genotoxicity Testing (IWGT) Workgroup.Semantic proximity Read ↗

Detection of In Vivo Mutation in the Pig-a Gene of Mouse Bone Marrow Erythroids.Semantic proximity Read ↗

In vitro mammalian cell mutation assays based on the Pig-a gene: A report of the 7th International Workshop on Genotoxicity Testing (IWGT) Workgroup.Semantic proximity Read ↗

Monitoring humans for somatic mutation in the endogenous PIG-a gene using red blood cells.Semantic proximity Read ↗

Detection of Pig-a Mutant Erythrocytes in the Peripheral Blood of Rats and Mice.Semantic proximity Read ↗

Detection of Pig-a mutant erythrocytes in the peripheral blood of rats and mice.Semantic proximity Read ↗

The in vivo Pig-a gene mutation assay, a potential tool for regulatory safety assessment.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.