Article
Detection of In Vivo Mutation in the Pig-a Gene of Mouse Bone Marrow Erythroids.
Methods in molecular biology (Clifton, N.J.) - 1 Jan 2017
Kimoto Takafumi, Miura Daishiro
Abstract excerpt
Detection of in vivo mutation is important for evaluating the health risks associated with chemicals. The Pig-a in vivo gene mutation assay has been developed over the last decade for this purpose. Most approaches for the assay, however, measure cells with a Pig-a mutant phenotype in erythrocytes from the peripheral blood, with the mutations causing the phenotype being difficult to determine directly. This...
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