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[The PIG-A gene as a new biomarker of mutagenesis: proof of concept and technical specifications].

Medecine sciences : M/S - 1 Apr 2017

Castel Pierre, Carcopino Xavier, Robert Stéphane, Bonetto Rémi, Cowen Didier, Orsiere Thierry

Abstract excerpt

Gene mutations are not directly detected by current genotoxicity assays and most of them need a cell culture step. The whole blood PIG-A assay consists in the detection of the mutation frequency within the PIG-A sentinel gene by identification of glycosyl-phosphatidyl-inositol (GPI-) deficient cells. PIG-A mutated/GPI-deficient cells can be detected by flow cytometry as they no longer express surface fluorescence...

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PMID: 28497740
DOI: 10.1051/medsci/20173304014

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GPI

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