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Development of an in vitro PIG-A gene mutation assay in human cells.

Mutagenesis - 1 Mar 2017

Rees Benjamin J, Tate Matthew, Lynch Anthony M, Thornton Catherine A, Jenkins Gareth J, Walmsley Richard M, Johnson George E

Abstract excerpt

Mutagens can be carcinogens, and traditionally, they have been identified in vitro using the Salmonella 'Ames' reverse mutation assay. However, prokaryotic DNA packaging, replication and repair systems are mechanistically very different to those in the humans we inevitably seek to protect. Therefore, for many years, mammalian cell line genotoxicity assays that can detect eukaryotic mutagens as well as clastogens...

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PMID: 28057708
DOI: 10.1093/mutage/gew059
PMCID: PMC5907909

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GPI

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