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Article

The VPS34 PI3K negatively regulates RAB-5 during endosome maturation.

Journal of cell science - 15 Jun 2017

Law Fiona, Seo Jung Hwa, Wang Ziqing, DeLeon Jennifer L, Bolis Yousstina, Brown Ashley, Zong Wei-Xing, Du Guangwei, Rocheleau Christian E

Abstract excerpt

The GTPase Rab5 and phosphatidylinositol-3 phosphate [PI(3)P] coordinately regulate endosome trafficking. Rab5 recruits Vps34, the class III phosphoinositide 3-kinase (PI3K), to generate PI(3)P and recruit PI(3)P-binding proteins. Loss of Rab5 and loss of Vps34 have opposite effects on endosome size, suggesting that our understanding of how Rab5 and PI(3)P cooperate is incomplete. Here, we report a novel...

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Identifiers

PMID: 28455411
DOI: 10.1242/jcs.194746
PMCID: PMC5482978

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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