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Article

C. elegans Rab GTPase activating protein TBC-2 promotes cell corpse degradation by regulating the small GTPase RAB-5.

Development (Cambridge, England) - 1 Jul 2009

Li Weida, Zou Wei, Zhao Dongfeng, Yan Jiacong, Zhu Zuoyan, Lu Jing, Wang Xiaochen

Abstract excerpt

During apoptosis, dying cells are quickly internalized by neighboring cells or phagocytes, and are enclosed in phagosomes that undergo a maturation process to generate the phagoslysosome, in which cell corpses are eventually degraded. It is not well understood how apoptotic cell degradation is regulated. Here we report the identification and characterization of the C. elegans tbc-2 gene, which is required for the...

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PMID: 19542357
DOI: 10.1242/dev.035949

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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