Article
Negative regulation of phosphatidylinositol 3-phosphate levels in early-to-late endosome conversion.
The Journal of cell biology - 18 Jan 2016
Liu Kai, Jian Youli, Sun Xiaojuan, Yang Chengkui, Gao Zhiyang, Zhang Zhili, Liu Xuezhao, Li Yang, Xu Jing, Jing Yudong, Mitani Shohei, He Sudan, Yang Chonglin
Abstract excerpt
Phosphatidylinositol 3-phosphate (PtdIns3P) plays a central role in endosome fusion, recycling, sorting, and early-to-late endosome conversion, but the mechanisms that determine how the correct endosomal PtdIns3P level is achieved remain largely elusive. Here we identify two new factors, SORF-1 and SORF-2, as essential PtdIns3P regulators in Caenorhabditis elegans. Loss of sorf-1 or sorf-2 leads to greatly...
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