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Article

PIKI-1, a class II PI 3-kinase, functions in endocytic trafficking.

PLoS genetics - 1 Feb 2026

Reimann Gabrielle R, Edeen Philip T, Conquest Sylvia, Grant Barth D, Fay David S

Abstract excerpt

Cellular membrane trafficking, including endocytosis and exocytosis, is a complex process coordinated by trafficking-associated proteins, cargo molecules, the cytoskeleton, and membrane lipids. The NIMA-related kinases NEKL-2 (human NEK8/9) and NEKL-3 (human NEK6/7) are conserved regulators of membrane trafficking in Caenorhabditis elegans that are required for the completion of molting. Using a genetic approach,...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 41686813
DOI: 10.1371/journal.pgen.1011740
PMCID: PMC12919929

Genes

HIP1
NEK6
NEK8

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 24 Oct 2026.

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Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

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