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Article

Caenorhabditis elegans RME-6 is a novel regulator of RAB-5 at the clathrin-coated pit.

Nature cell biology - 1 Jun 2005

Sato Miyuki, Sato Ken, Fonarev Paul, Huang Chih-Jen, Liou Willisa, Grant Barth D

Abstract excerpt

Here we identify a new regulator of endocytosis called RME-6. RME-6 is evolutionarily conserved among metazoans and contains Ras-GAP (GTPase-activating protein)-like and Vps9 domains. Consistent with the known catalytic function of Vps9 domains in Rab5 GDP/GTP exchange, we found that RME-6 binds specifically to Caenorhabditis elegans RAB-5 in the GDP-bound conformation, and rme-6 mutants have phenotypes that...

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Identifiers

PMID: 15895077
DOI: 10.1038/ncb1261
PMCID: PMC1398054

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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