Article
The class III PI(3)K Vps34 promotes autophagy and endocytosis but not TOR signaling in Drosophila.
The Journal of cell biology - 19 May 2008
Juhász Gábor, Hill Jahda H, Yan Ying, Sass Miklós, Baehrecke Eric H, Backer Jonathan M, Neufeld Thomas P
Abstract excerpt
Degradation of cytoplasmic components by autophagy requires the class III phosphatidylinositol 3 (PI(3))-kinase Vps34, but the mechanisms by which this kinase and its lipid product PI(3) phosphate (PI(3)P) promote autophagy are unclear. In mammalian cells, Vps34, with the proautophagic tumor suppressors Beclin1/Atg6, Bif-1, and UVRAG, forms a multiprotein complex that initiates autophagosome formation. Distinct...
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