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Article

Mouse models of PI(3,5)P2 deficiency with impaired lysosome function.

Methods in enzymology - 1 Jan 2014

Lenk Guy M, Meisler Miriam H

Abstract excerpt

The endolysosomal system and autophagy are essential components of macromolecular turnover in eukaryotic cells. The low-abundance signaling lipid PI(3,5)P2 is a key regulator of this pathway. Analysis of mouse models with defects in PI(3,5)P2 biosynthesis has revealed the unique dependence of the mammalian nervous system on this signaling pathway. This insight led to the discovery of the molecular basis for...

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Identifiers

PMID: 24359958
DOI: 10.1016/B978-0-12-397926-1.00014-7
PMCID: PMC4059992

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Mouse models of PI(3,5)P2 deficiency with impaired lysosome function.PMID 24359958Read ↗

Defective autophagy in neurons and astrocytes from mice deficient in PI(3,5)P2Semantic proximity Read ↗

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Phosphatidylinositol 3,5-bisphosphate: low abundance, high significance.Semantic proximity Read ↗

Yunis-Varón syndrome is caused by mutations in FIG4, encoding a phosphoinositide phosphatase.Semantic proximity Read ↗

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PI(5)P Regulates Autophagosome BiogenesisSemantic proximity Read ↗

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