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Article

Tumour-associated changes in intestinal epithelial cells cause local accumulation of KLRG1+ GATA3+ regulatory T cells in mice.

Immunology - 1 Sept 2017

Meinicke Holger, Bremser Anna, Brack Maria, Akeus Paulina, Pearson Claire, Bullers Samuel, Hoffmeyer Katrin, Stemmler Marc P, Quiding-Järbrink Marianne, Izcue Ana

Abstract excerpt

CD4+ Foxp3+ regulatory T (Treg) cells include differentiated populations of effector Treg cells characterized by the expression of specific transcription factors. Tumours, including intestinal malignancies, often present with local accumulation of Treg cells that can prevent tumour clearance, but how tumour progression leads to Treg cell accumulation is incompletely understood. Here using genetically modified...

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Source

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Identifiers

PMID: 28437001
DOI: 10.1111/imm.12750
PMCID: PMC5543491

Genes

GATA3
KLRG1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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