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Article

Intestinal Regulatory T Cells as Specialized Tissue-Restricted Immune Cells in Intestinal Immune Homeostasis and Disease.

Frontiers in immunology - 1 Jan 2021

Jacobse Justin, Li Jing, Rings Edmond H H M, Samsom Janneke N, Goettel Jeremy A

Abstract excerpt

FOXP3+ regulatory T cells (Treg cells) are a specialized population of CD4+ T cells that restrict immune activation and are essential to prevent systemic autoimmunity. In the intestine, the major function of Treg cells is to regulate inflammation as shown by a wide array of mechanistic studies in mice. While Treg cells originating from the thymus can home to the intestine, the majority of Treg cells residing in...

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Identifiers

PMID: 34421921
DOI: 10.3389/fimmu.2021.716499
PMCID: PMC8371910

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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