Article

Site-dependent Treg cell transcriptional reprograming in a metastatic colorectal cancer model holds prognostic significance

2025-03-15

Abstract excerpt

In colorectal cancer (CRC), tumor-infiltrating regulatory T (Treg) cells suppress anti-tumor immunity, promoting immune evasion and tumor progression. Effective therapies require selectively targeting tumor-infiltrating Treg (TI-Treg) cells while preserving systemic Treg cells, necessitating insight into their adaptations within the tumor microenvironment. Here, CRC-organoids were implanted in the liver of Foxp3eG...

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Literature Corpus work: 836bed7f-2132-5cc5-b72d-ccfadc5b7c55
DOI: 10.1101/2025.03.13.643028

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