Article
T-regulatory cells shift from a protective anti-inflammatory to a cancer-promoting proinflammatory phenotype in polyposis.
Cancer research - 1 Jul 2009
Gounaris Elias, Blatner Nichole R, Dennis Kristen, Magnusson Fay, Gurish Michael F, Strom Terry B, Beckhove Philipp, Gounari Fotini, Khazaie Khashayarsha
Abstract excerpt
T-regulatory (Treg) cells play a major role in cancer by suppressing protective antitumor immune responses. A series of observations (from a single laboratory) suggest that Treg cells are protective in cancer by virtue of their ability to control cancer-associated inflammation in an interleukin (IL)-10-dependent manner. Here, we report that the ability of Treg cells to produce IL-10 and control inflammation is...
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