Article

Tumors accumulate expanded GATA3-dependent tissue Tregs

2026-03-15

Abstract excerpt

Targeting Tregs is a potential strategy to improve cancer therapies. However, which Tregs accumulate in response to tumoral processes, and how tumors affect their phenotype, is poorly understood. Here we show that tumor Tregs are equivalent to effector tissue Tregs in steady state organs. We used a mouse model of intestinal neoplasia to demonstrate that one early event in carcinogenesis is sufficient to induce loc...

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Literature Corpus work: 61a5d06b-b24f-54e2-99d7-bd195e93deeb
DOI: 10.64898/2026.03.13.707380

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