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Article

The IL-33/ST2 pathway shapes the regulatory T cell phenotype to promote intestinal cancer

5 Jun 2019

Abstract excerpt

The composition of immune infiltrates strongly affects the prognosis of patients with colorectal cancer (CRC). Interleukin (IL)-33 and regulatory T cells (Tregs) in the tumor microenvironment have been separately implicated in CRC; however their contribution to intestinal carcinogenesis is still controversial. Here, we reveal that IL-33 signaling promotes CRC by changing the phenotype of Tregs. In mice with CRC,...

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PMID: 31165767
DOI: 10.1038/s41385-019-0176-y

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