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Article

Expression of RORγt Marks a Pathogenic Regulatory T Cell Subset in Human Colon Cancer

12 Dec 2012

Abstract excerpt

The role of regulatory T cells (T(regs)) in human colon cancer (CC) remains controversial: high densities of tumor-infiltrating T(regs) can correlate with better or worse clinical outcomes depending on the study. In mouse models of cancer, T(regs) have been reported to suppress inflammation and protect the host, suppress T cells and protect the tumor, or even have direct cancer-promoting attributes. These...

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PMID: 23241743
DOI: 10.1126/scitranslmed.3004566

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