Article

Wnt/β-catenin activation epigenetically reprograms Regulatory T cells in IBD and progression to dysplasia.

2020-12-01

Abstract excerpt

<title>Abstract</title> <p>The molecular and functional diversity of regulatory T-cells (T<sub>reg</sub>s) in health and in disease remains unclear. We previously described in colorectal cancer (CRC) patients a subpopulation of RORγt<sup>+</sup> T<sub>reg</sub>s with elevated expression of β-catenin and pro-inflammatory properties. Here we observed progressive expansion of RORγt<sup>+</sup> T<sub>reg</sub>s in in...

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Literature Corpus work: 1eb74e28-80cf-547e-8f0d-b7060078b84e
DOI: 10.21203/rs.3.rs-110212/v1

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