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Article

Wnt-β-catenin activation epigenetically reprograms Treg cells in inflammatory bowel disease and dysplastic progression.

Nature immunology - 1 Apr 2021

Quandt Jasmin, Arnovitz Stephen, Haghi Leila, Woehlk Janine, Mohsin Azam, Okoreeh Michael, Mathur Priya S, Emmanuel Akinola Olumide, Osman Abu, Krishnan Manisha, Morin Samuel B, Pearson Alexander T, Sweis Randy F, Pekow Joel, Weber Christopher R, Khazaie Khashayarsha, Gounari Fotini

Abstract excerpt

The diversity of regulatory T (Treg) cells in health and in disease remains unclear. Individuals with colorectal cancer harbor a subpopulation of RORγt+ Treg cells with elevated expression of β-catenin and pro-inflammatory properties. Here we show progressive expansion of RORγt+ Treg cells in individuals with inflammatory bowel disease during inflammation and early dysplasia. Activating Wnt-β-catenin signaling in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 33664518
DOI: 10.1038/s41590-021-00889-2
PMCID: PMC8262575

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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