Article
Coordinate linkage of HIV evolution reveals regions of immunological vulnerability.
Proceedings of the National Academy of Sciences of the United States of America - 12 Jul 2011
Dahirel Vincent, Shekhar Karthik, Pereyra Florencia, Miura Toshiyuki, Artyomov Mikita, Talsania Shiv, Allen Todd M, Altfeld Marcus, Carrington Mary, Irvine Darrell J, Walker Bruce D, Chakraborty Arup K
Abstract excerpt
Cellular immune control of HIV is mediated, in part, by induction of single amino acid mutations that reduce viral fitness, but compensatory mutations limit this effect. Here, we sought to determine if higher order constraints on viral evolution exist, because some coordinately linked combinations of mutations may hurt viability. Immune targeting of multiple sites in such a multidimensionally conserved region...
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