Article
Pairwise and higher-order correlations among drug-resistance mutations in HIV-1 subtype B protease.
BMC bioinformatics - 27 Aug 2009
Haq Omar, Levy Ronald M, Morozov Alexandre V, Andrec Michael
Abstract excerpt
BACKGROUND: The reaction of HIV protease to inhibitor therapy is characterized by the emergence of complex mutational patterns which confer drug resistance. The response of HIV protease to drugs often involves both primary mutations that directly inhibit the action of the drug, and a host of accessory resistance mutations that may occur far from the active site but may contribute to restoring the fitness or...
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