Chromatin remodellers as therapeutic targets.

doi:10.1038/s41573-024-00978-5

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Article

Chromatin remodellers as therapeutic targets.

Nature reviews. Drug discovery - 1 Sept 2024

Malone Hayden A, Roberts Charles W M

Abstract excerpt

Large-scale cancer genome sequencing studies have revealed that chromatin regulators are frequently mutated in cancer. In particular, more than 20% of cancers harbour mutations in genes that encode subunits of SWI/SNF (BAF) chromatin remodelling complexes. Additional links of SWI/SNF complexes to disease have emerged with the findings that some oncogenes drive transformation by co-opting SWI/SNF function and that...

Topics

Humans
Chromatin Assembly and Disassembly
Neoplasms
Animals
Transcription Factors
Antineoplastic Agents
Mutation
Chromosomal Proteins, Non-Histone
Molecular Targeted Therapy

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Identifiers

PMID: 39014081
DOI: 10.1038/s41573-024-00978-5
PMCID: PMC11534152

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