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An RNA binding module of SWI/SNF is required for activation of cell-type specific enhancers and super-enhancers in early development

2022-09-06

Abstract excerpt

The mammalian SWI/SNF complex is an ATP-dependent chromatin remodeler and master regulator in development that when mutated is the cause for several human diseases including cancer. Although SWI/SNF is highly enriched at enhancers and its basic chromatin remodeling activities have been studied for over 30 years, there is little known about how it regulates enhancer activity or enhancer-promoter interactions. We fi...

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Literature Corpus work
00f9bc04-dffa-54c6-b7bf-1e5c1df58ab9
DOI
10.1101/2022.09.06.506785
Open publication

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An RNA binding module of SWI/SNF is required for activation of cell-type specific enhancers and super-enhancers in early developmentDOI 10.1101/2022.09.06.506785
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