Article
SWI/SNF chromatin remodeling and cancer.
Current opinion in genetics & development - 1 Feb 2002
Klochendler-Yeivin Agnès, Muchardt Christian, Yaniv Moshe
Abstract excerpt
The SWI/SNF complex contributes to the regulation of gene expression by altering the chromatin structure. Depending on the context, it can be involved in either transcriptional activation or repression. Growing genetic and molecular evidence indicate that subunits of the SWI/SNF complex act as tumor suppressors in human and mice. Results from biochemical and transfection studies suggest also that SWI/SNF...
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