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SWI/SNF Chromatin-remodeling Factors: Multiscale Analyses and Diverse Functions

1 Sept 2012

Abstract excerpt

Chromatin-remodeling enzymes play essential roles in many biological processes, including gene expression, DNA replication and repair, and cell division. Although one such complex, SWI/SNF, has been extensively studied, new discoveries are still being made. Here, we review SWI/SNF biochemistry; highlight recent genomic and proteomic advances; and address the role of SWI/SNF in human diseases, including cancer and...

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PMID: 22952240
DOI: 10.1074/jbc.r111.309302

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