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Article

Selecting cases and controls for DNA sequencing studies using family histories of disease.

Statistics in medicine - 15 Jun 2017

Kim Wonji, Qiao Dandi, Cho Michael H, Kwak Soo Heon, Park Kyong Soo, Silverman Edwin K, Sham Pak, Won Sungho

Abstract excerpt

Recent improvements in sequencing technology have enabled the investigation of so-called missing heritability, and a large number of affected subjects have been sequenced in order to detect significant associations between human diseases and rare variants. However, the cost of genome sequencing is still high, and a statistically powerful strategy for selecting informative subjects would be useful. Therefore, in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 28222494
DOI: 10.1002/sim.7248
PMCID: PMC5810411

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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