Comparisons of case-selection approaches based on allele sharing and/or disease severity index: application to the GAW14 simulated data.

Abstract excerpt

For mapping complex disease traits, linkage studies are often followed by a case-control association strategy in order to identify disease-associated genes/single-nucleotide polymorphisms (SNPs). Substantial efforts are required in selecting the most informative cases from a large collection of affected individuals in order to maximize the power of the study, while taking into consideration study cost. In this...

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