Article

Case-control association mapping without cases

2016-03-25

Abstract excerpt

The case-control association study is a powerful method for identifying genetic variants that influence disease risk. However, the collection of cases can be time-consuming and expensive; if a disease occurs late in life or is rapidly lethal, it may be more practical to identify family members of cases. Here, we show that replacing cases with their first-degree relatives enables genome-wide association studies by...

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Literature Corpus work: 463401b9-5e47-5625-abaa-b8871dd758d0
DOI: 10.1101/045831

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