Test of rare variant association based on affected sib-pairs.

Abstract excerpt

With the development of sequencing techniques, there is increasing interest to detect associations between rare variants and complex traits. Quite a few statistical methods to detect associations between rare variants and complex traits have been developed for unrelated individuals. Statistical methods for detecting rare variant associations under family-based designs have not received as much attention as...

Topics

• Algorithms
• Genetic Association Studies
• Genetic Diseases, Inborn
• Genetic Linkage
• Genotype
• Humans
• Models, Genetic
• Mutation
• Rare Diseases