Article
Improving Disease Prediction by Incorporating Family Disease History in Risk Prediction Models with Large-Scale Genetic Data.
Genetics - 1 Nov 2017
Gim Jungsoo, Kim Wonji, Kwak Soo Heon, Choi Hosik, Park Changyi, Park Kyong Soo, Kwon Sunghoon, Park Taesung, Won Sungho
Abstract excerpt
Despite the many successes of genome-wide association studies (GWAS), the known susceptibility variants identified by GWAS have modest effect sizes, leading to notable skepticism about the effectiveness of building a risk prediction model from large-scale genetic data. However, in contrast to genetic variants, the family history of diseases has been largely accepted as an important risk factor in clinical...
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