Power analysis for case-control association studies of samples with known family histories.

doi:10.1007/s00439-010-0824-5

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Article

Power analysis for case-control association studies of samples with known family histories.

Human genetics - 1 Jun 2010

Peng Bo, Li Biao, Han Younghun, Amos Christopher I

Abstract excerpt

Genome-wide case-control studies have been widely used to identify genetic variants that predispose to human diseases. Such studies are powerful in detecting common genetic variants with moderate effects, but quickly lose power as allele frequency and genotype relative risk decrease. Because patients with one or more affected relatives are more likely to inherit disease-predisposing alleles of a genetic disease...

Topics

Alleles
Case-Control Studies
Gene Frequency
Genetic Diseases, Inborn
Genotype
Humans
Research
Research Design
Risk
Sample Size

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Identifiers

PMID: 20383776
DOI: 10.1007/s00439-010-0824-5
PMCID: PMC3914772

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