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Article

Estimating missing heritability for disease from genome-wide association studies.

American journal of human genetics - 11 Mar 2011

Lee Sang Hong, Wray Naomi R, Goddard Michael E, Visscher Peter M

Abstract excerpt

Genome-wide association studies are designed to discover SNPs that are associated with a complex trait. Employing strict significance thresholds when testing individual SNPs avoids false positives at the expense of increasing false negatives. Recently, we developed a method for quantitative traits that estimates the variation accounted for when fitting all SNPs simultaneously. Here we develop this method further...

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Identifiers

PMID: 21376301
DOI: 10.1016/j.ajhg.2011.02.002
PMCID: PMC3059431

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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