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Article

Leveraging family history in genetic association analyses of binary traits.

BMC genomics - 1 Oct 2022

Zhang Yixin, Meigs James B, Liu Ching-Ti, Dupuis Josée, Sarnowski Chloé

Abstract excerpt

BACKGROUND: Considering relatives' health history in logistic regression for case-control genome-wide association studies (CC-GWAS) may provide new information that increases accuracy and power to detect disease associated genetic variants. We conducted simulations and analyzed type 2 diabetes (T2D) data from the Framingham Heart Study (FHS) to compare two methods, liability threshold model conditional on both...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 36182916
DOI: 10.1186/s12864-022-08897-8
PMCID: PMC9526325

Genes

FH
ADAMTS2
GPC6
PRR16
TCF7L2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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