Article
Mechanisms of LRRK2-dependent neurodegeneration: role of enzymatic activity and protein aggregation.
Biochemical Society transactions - 8 Feb 2017
Islam Md Shariful, Moore Darren J
Abstract excerpt
Mutations in the leucine-rich repeat kinase 2 (LRRK2) gene are the most common cause of familial Parkinson's disease (PD) with autosomal dominant inheritance. Accordingly, LRRK2 has emerged as a promising therapeutic target for disease modification in PD. Since the first discovery of LRRK2 mutations some 12 years ago, LRRK2 has been the subject of intense investigation. It has been established that LRRK2 can...
Topics
- GTP Phosphohydrolases
- Humans
- Leucine-Rich Repeat Serine-Threonine Protein Kinase-2
- Models, Genetic
- Mutation
- Neurodegenerative Diseases
- Protein Aggregates
- Protein Aggregation, Pathological
- alpha-Synuclein
- tau Proteins