Article
Biochemical and molecular features of LRRK2 and its pathophysiological roles in Parkinson's disease.
BMB reports - 1 Apr 2010
Seol Wongi
Abstract excerpt
Parkinson's disease (PD) is the second most common neurodegenerative disease, and 5-10% of the PD cases are genetically inherited as familial PD (FPD). LRRK2 (leucine-rich repeat kinase 2) was first reported in 2004 as a gene corresponding to PARK8, an autosomal gene whose dominant mutations cause familial PD. LRRK2 contains both active kinase and GTPase domains as well as protein-protein interaction motifs such...
Topics
- Humans
- Leucine-Rich Repeat Serine-Threonine Protein Kinase-2
- Mutation
- Parkinson Disease
- Protein Serine-Threonine Kinases
- Protein Structure, Tertiary