Pathological Functions of LRRK2 in Parkinson's Disease.

Abstract excerpt

Mutations in the gene encoding leucine-rich repeat kinase 2 (LRRK2) are common genetic risk factors for both familial and sporadic Parkinson's disease (PD). Pathogenic mutations in LRRK2 have been shown to induce changes in its activity, and abnormal increase in LRRK2 kinase activity is thought t...

Topics

• Animals
• Humans
• Leucine-Rich Repeat Serine-Threonine Protein Kinase-2
• Mutation
• Parkinson Disease
• Signal Transduction
• alpha-Synuclein