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Article

The role of the LRRK2 gene in Parkinsonism

12 Nov 2014

Abstract excerpt

Parkinson's disease (PD), like many common age-related conditions, has been recognized to have a substantial genetic component. Multiple lines of evidence suggest that Leucine-rich repeat kinase 2 (LRRK2) is a crucial factor to understanding the etiology of PD. LRRK2 is a large, widely expressed, multi-domain and multifunctional protein. LRRK2 mutations are the major cause to inherited and sporadic PD. In this...

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PMID: 25391693
DOI: 10.1186/1750-1326-9-47

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