Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

LRRK2 and Proteostasis in Parkinson's Disease.

International journal of molecular sciences - 18 Jun 2022

Pérez-Carrión María Dolores, Posadas Inmaculada, Solera Javier, Ceña Valentín

Abstract excerpt

Parkinson's disease is a neurodegenerative condition initially characterized by the presence of tremor, muscle stiffness and impaired balance, with the deposition of insoluble protein aggregates in Lewy's Bodies the histopathological hallmark of the disease. Although different gene variants are linked to Parkinson disease, mutations in the Leucine-Rich Repeat Kinase 2 (LRRK2) gene are one of the most frequent...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to alpha-Synuclein
Share to Leucine-Rich Repeat Serine-Threonine Protein Kinase-2

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Lysosomes

Share to Mutation

Share to Parkinson Disease

Share to Proteostasis

Source

Open in PubMed Open full text

Identifiers

PMID: 35743250
DOI: 10.3390/ijms23126808
PMCID: PMC9224256

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

LRRK2 and Proteostasis in Parkinson's Disease.PMID 35743250Read ↗

Mechanisms of LRRK2-dependent neurodegeneration: role of enzymatic activity and protein aggregation.Semantic proximity Read ↗

A Link between Autophagy and the Pathophysiology of LRRK2 in Parkinson's DiseaseSemantic proximity Read ↗

The emerging role of LRRK2 in tauopathies.Semantic proximity Read ↗

Pathological Functions of LRRK2 in Parkinson's Disease.Semantic proximity Read ↗

LRRK2 and Protein Aggregation in Parkinson’s Disease: Insights From Animal ModelsSemantic proximity Read ↗

LRRK2 in Parkinson's disease: upstream regulation and therapeutic targeting.Semantic proximity Read ↗

Recent advances in targeting LRRK2 for Parkinson's disease treatment.Semantic proximity Read ↗

LRRK2, a puzzling protein: insights into Parkinson's disease pathogenesis.Semantic proximity Read ↗

Leucine‐rich repeat kinase 2 and Parkinson's diseaseSemantic proximity Read ↗

The role of the LRRK2 gene in ParkinsonismSemantic proximity Read ↗

Mechanisms of LRRK2-mediated neurodegeneration.Semantic proximity Read ↗

Exploring LRRK2-dependent Mechanisms in Parkinson's Disease Therapy.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.