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Article

LRRK2 and α-Synuclein: Distinct or Synergistic Players in Parkinson’s Disease?

17 Jun 2020

Abstract excerpt

Parkinson’s disease (PD) is the most common neurodegenerative movement disorder, characterized by prominent degeneration of dopaminergic neurons in the substantia nigra and aggregation of the protein alpha-synuclein within intraneuronal inclusions known as Lewy bodies. Ninety percent of PD cases are idiopathic while the remaining 10% are associated with gene mutations that affect cellular functions ranging from...

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PMID: 32625052
DOI: 10.3389/fnins.2020.00577

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